Study of different process parameters for polylactic acid microspheres formulations

Abstract

In order to evaluate the effects of different processing parameters on drug-loaded microspheres, the solvent evaporation technique was chosen as the formulation method. Indomethacinloaded Polylactic acid microspheres were prepared by varying drug masses, then by changing the stirring speed. They were analyzed for their drug content, physical morphology, size, polymer-drug physicochemical compatibility, and in vitro drug release. Microspheres revealed a spherical profile along with a porous structure. The effect of changing the drug mass was noted on drug encapsulation and loading efficiencies. Indomethacin had better encapsulation when introduced in small amounts. On the other hand, the effect of changing the stirring speed was remarkable on the size of obtained microspheres and drug release profile. The particle size decreased as the speed of mixing increased. In addition, a faster drug release was observed for larger microspheres.