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Title: Spectrophotometric characterization of propanol-hydroxypropyl-β-cyclodextrin inclusion complex
Authors: Hassan, Inas EL
Allouch, Ahmad
Abou Dalle, Adib
Tabcheh, Mohamad
Nakat, Hanna El 
Omar, Fawaz El
Affiliations: Department of Chemistry 
Keywords: Inclusion complexes
HPLC Chromatograph
Chiral selectors
Issue Date: 2012
Part of: Asian journal of research in chemistry
Volume: 5
Issue: 6
Start page: 718
End page: 721
Cyclodextrins (CD) are a group of natural products formed during bacterial digestion of starch. These cyclic oligosaccharides consist of (a-1,4)-linked a-D-glucopyranose units and contain a hydrophobic central cavity and a hydrophilic outer surface. Cyclodextrins are well known for their ability to interact with poorly-water soluble compounds to form inclusion complexes thus increasing their apparent solubilities. For this reason, the most important application of CD in pharmaceutical industry is to enhance drug solubility in aqueous solutions. Propranolol is a very important ß-blocker drug, mainly used in the treatment of hypertension and cardiac arrhythmias. In this paper, a simple and rapid spectrophotometric method has been investigated for the study of inclusion complex of propranolol with hydroxypropyl-ß-cyclodextrin (HP???CD). The stoichiometry of propranolol- HP???CD complex has been determined by continuous variation (Job's plot) method and the overall association constant was determined by using Scott's method.
Type: Journal Article
Appears in Collections:Department of Chemistry

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