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UOB Libraries created the UOBScholar Hub, an Institutional Repository (IR) for archiving and collecting all the research output of the UOB community. It aims to improve the visibility, usage and impact of research conducted at UOB. Materials included are: academic journal articles, conference papers and presentations, books and book chapters, ongoing research papers, reports and patents.
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https://scholarhub.balamand.edu.lb/handle/uob/2532| Title: | Separation of racemate hydrophobic thiourea substrates | Authors: | Hassan, Inas EL Houmaissi, Fatme Bouchekara, Mohammad Nakat, Hanna El Omar, Fawaz El Allouch, Ahmad |
Affiliations: | Department of Chemistry | Keywords: | Thiourea HP-Beta-CD HPLC Atropisomeric separation |
Issue Date: | 2016 | Part of: | International journal of pharmaceutical chemistry | Volume: | 6 | Issue: | 3 | Start page: | 87 | End page: | 91 | Abstract: | The separation of racemic-N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, a hydrophobic substrate trap, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RPHPLC). Hydroxypropyl-beta-cyclodextrin (HP-β-CD) was used as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-ethanol (50% in volume) as a mobile phase. The effects of mobile phase composition, on separation were systematically investigated to establish the optimum conditions of resolution. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/2532 | Open URL: | Link to full text | Type: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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