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Title: Separation of racemate hydrophobic thiourea substrates
Authors: Hassan, Inas EL
Houmaissi, Fatme
Bouchekara, Mohammad
Nakat, Hanna El 
Omar, Fawaz El
Allouch, Ahmad
Affiliations: Department of Chemistry 
Keywords: Thiourea
Atropisomeric separation
Issue Date: 2016
Part of: International journal of pharmaceutical chemistry
Volume: 6
Issue: 3
Start page: 87
End page: 91
The separation of racemic-N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, a hydrophobic substrate trap, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RPHPLC). Hydroxypropyl-beta-cyclodextrin (HP-β-CD) was used as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-ethanol (50% in volume) as a mobile phase. The effects of mobile phase composition, on separation were systematically investigated to establish the optimum conditions of resolution.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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