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|Title:||Separation of racemate hydrophobic thiourea substrates||Authors:||Hassan, Inas EL
Nakat, Hanna El
Omar, Fawaz El
|Affiliations:||Department of Chemistry||Keywords:||Thiourea
|Issue Date:||2016||Part of:||International journal of pharmaceutical chemistry||Volume:||6||Issue:||3||Start page:||87||End page:||91||Abstract:||
The separation of racemic-N-(2-ethylphenyl)-N'-(2-methylphenyl) thiourea, a hydrophobic substrate trap, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RPHPLC). Hydroxypropyl-beta-cyclodextrin (HP-β-CD) was used as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-ethanol (50% in volume) as a mobile phase. The effects of mobile phase composition, on separation were systematically investigated to establish the optimum conditions of resolution.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/2532||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Chemistry|
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