Please use this identifier to cite or link to this item:
|Title:||Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium||Authors:||Gierach, Gretchen L.
Brinton, Louise A.
Farhat, Ghada N.
Vacek, Pamela M.
Weaver, Donald L.
Taplin, Stephen H.
Sherman, Mark E.
|Affiliations:||Department of Public Health||Keywords:||Body mass index procedure
Breast imaging reporting and data system
Breast cancer risk
|Issue Date:||2012||Part of:||Journal of the national cancer institute||Volume:||104||Issue:||16||Start page:||1218||End page:||1227||Abstract:||
Background Women with elevated mammographic density have an increased risk of developing breast cancer. However, among women diagnosed with breast cancer, it is unclear whether higher density portends reduced survival, independent of other factors. Methods We evaluated relationships between mammographic density and risk of death from breast cancer and all causes within the US Breast Cancer Surveillance Consortium. We studied 9232 women diagnosed with primary invasive breast carcinoma during 1996–2005, with a mean follow-up of 6.6 years. Mammographic density was assessed using the Breast Imaging Reporting and Data System (BI-RADS) density classification. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression; women with scattered fibroglandular densities (BI-RADS 2) were the referent group. All statistical tests were two-sided. Results A total of 1795 women died, of whom 889 died of breast cancer. In multivariable analyses (adjusted for site, age at and year of diagnosis, American Joint Committee on Cancer stage, body mass index, mode of detection, treatment, and income), high density (BI-RADS 4) was not related to risk of death from breast cancer (HR = 0.92, 95% CI = 0.71 to 1.19) or death from all causes (HR = 0.83, 95% CI = 0.68 to 1.02). Analyses stratified by stage and other prognostic factors yielded similar results, except for an increased risk of breast cancer death among women with low density (BI-RADS 1) who were either obese (HR = 2.02, 95% CI = 1.37 to 2.97) or had tumors of at least 2.0cm (HR = 1.55, 95% CI = 1.14 to 2.09). Conclusions High mammographic breast density was not associated with risk of death from breast cancer or death from any cause after accounting for other patient and tumor characteristics. Thus, risk factors for the development of breast cancer may not necessarily be the same as factors influencing the risk of death after breast cancer has developed.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/2481||Ezproxy URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Public Health|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.