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Title: A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital
Authors: Zarrilli, Raffaele
Vitale, Domenico
Di Popolo, Anna
Bagattini, Maria
Daoud, Ziad
Khan, Asad U.
Afif, Claude
Triassi, Maria
Affiliations: Faculty of Medicine 
Issue Date: 2008
Part of: Journal of antimicrobial agents and chemotherapy
Volume: 52
Issue: 11
Start page: 4115
End page: 4120
We investigated the basis of the carbapenem resistance of 17 multidrug-resistant Acinetobacter baumannii clinical isolates collected from 2004 to 2005 at the Saint George University Hospital in Beirut, Lebanon. A. baumannii isolates were clonally related and were susceptible to colistin and trimethoprim-sulfamethoxazole, susceptible or intermediate to ampicillin-sulbactam and meropenem, and resistant to all other antimicrobials. Conjugation experiments demonstrated that resistance to imipenem could be transferred along with a plasmid containing the carbapenem-hydrolyzing oxacillinase blaOXA-58 gene. The plasmid that we called pABIR was 29,823 bp in size and showed a novel mosaic structure composed of two origins of replication, four insertion sequence (IS) elements, and 28 open reading frames. The blaOXA-58 gene was flanked by IS18 and ISAba3 elements at the 5ʹ and 3ʹ ends, respectively. The production of the carbapenem-hydrolyzing oxacillinase OXA-58 was apparently the only mechanism for carbapenem resistance in A. baumannii isolates causing the outbreak at the Lebanese Hospital.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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