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|Title:||Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition||Authors:||Bouclaous, Carmel
Nassar, Camille F
|Affiliations:||Faculty of Medicine||Keywords:||Glucocorticoids
|Subjects:||Intestinal absorption||Issue Date:||2003||Part of:||Nutrition research journal||Volume:||23||Issue:||8||Start page:||1105||End page:||1115||Abstract:||
The effects of macronutrient composition of the diet and glucocorticoid administration on weight gain, intestinal absorption and plasma lipids were investigated. Thirty seven male Wistar rats were divided into 4 groups, implanted with pellets continuously delivering either prednisolone (0.25mg/day) or placebo and fed two isocaloric diets providing either high fat (HF: 50% of energy) or high carbohydrate (HC: 70% of energy). The four groups [group I (HC, placebo), group II (HC, prednisolone), group III (HF, placebo), group IV (HF, prednisolone)] were pair fed and given the mean amount of food eaten by the group with the least amount of energy intake on the previous day. After 4 weeks, the animals were sacrificed and serum glucose, total cholesterol (TC), HDL-cholesterol (HDL) and triglycerides (TG) were measured. All groups showed a decrease in relative intestinal absorption with time. Prednisolone-treated groups revealed significantly lower intestinal absorption. However, prednisolone-treated high-carbohydrate (HC) fed rats showed significantly higher weight gain, concomitant with a significant increase in feed efficiency. The HC diet induced a statistically significant increase in TG concentration. The results show that prednisolone treatment induces more weight gain on a HC as compared to a high fat (HF) diet possibly through a rise in feed efficiency.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/2257||DOI:||10.1016/S0271-5317(03)00104-0||Ezproxy URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Faculty of Medicine|
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