Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2243
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dc.contributor.authorBaydoun, Elias A-H.en_US
dc.contributor.authorKaram, Martinen_US
dc.contributor.authorWahab, Atia-tulen_US
dc.contributor.authorKhan, Mahwish Shafi Ahmeden_US
dc.contributor.authorAhmad, Malil Shoaiben_US
dc.contributor.authorSamreenen_US
dc.contributor.authorSmith, Colinen_US
dc.contributor.authorAbdel-Massih, Roulaen_US
dc.contributor.authorChoudhary, Muhammad Iqbalen_US
dc.date.accessioned2020-12-23T09:09:19Z-
dc.date.available2020-12-23T09:09:19Z-
dc.date.issued2014-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2243-
dc.description.abstractTherapeutic potential of nandrolone and its derivatives against leishmaniasis has been studied. A number of derivatives of nandrolone (1) were synthesized through biotransformation. Microbial transformation of nandrolone (1) with Cunninghamella echinulata and Cunninghamella blakesleeana yielded three new metabolites, 10β,12β,17β-trihydroxy-19-nor-4-androsten-3-one (2), 10β,16α,17β-trihydroxy-19-nor-4-androsten-3-one (3), and 6β,10β,17β-trihydroxy-19-nor-4-androsten-3-one (4), along with four known metabolites, 10β,17β-dihydroxy-19-nor-4-androsten-3-one (5), 6β,17β-dihydroxy-19-nor-4-androsten-3-one (6) 10β-hydroxy-19-nor-4-androsten-3,17-dione (7) and 16β,17β-dihydroxy-19-nor-4-androsten-3-one (8). Compounds 1–8 were evaluated for their anti-leishmanial activity. Compounds 1 and 8 showed a significant activity in vitro against Leishmania major. The leishmanicidal potential of compounds 1–8 (IC50 = 32.0 ± 0.5, >100, 77.39 ± 5.52, 70.90 ± 1.16, 54.94 ± 1.01, 80.23 ± 3.39, 61.12 ± 1.39 and 29.55 ± 1.14 μM, respectively) can form the basis for the development of effective therapies against the protozoal tropical disease leishmaniasis.en_US
dc.format.extent5 p.en_US
dc.language.isoengen_US
dc.subjectAnabolic compounden_US
dc.subjectCunninghamella echinulataen_US
dc.subjectCunninghamella blakesleeanaen_US
dc.subjectLeishmania majoren_US
dc.subjectLeishmanicidal activityen_US
dc.subject.lcshNandroloneen_US
dc.titleMicrobial transformation of nandrolone with Cunninghamella echinulata and Cunninghamella blakesleeana and evaluation of leishmaniacidal activity of transformed productsen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.steroids.2014.06.020-
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.volume88en_US
dc.description.startpage95en_US
dc.description.endpage100en_US
dc.date.catalogued2017-10-31-
dc.description.statusPublisheden_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1016/j.steroids.2014.06.020en_US
dc.identifier.OlibID174624-
dc.relation.ispartoftextSteroidsen_US
dc.provenance.recordsourceOliben_US
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