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https://scholarhub.balamand.edu.lb/handle/uob/2243
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baydoun, Elias A-H. | en_US |
dc.contributor.author | Karam, Martin | en_US |
dc.contributor.author | Wahab, Atia-tul | en_US |
dc.contributor.author | Khan, Mahwish Shafi Ahmed | en_US |
dc.contributor.author | Ahmad, Malil Shoaib | en_US |
dc.contributor.author | Samreen | en_US |
dc.contributor.author | Smith, Colin | en_US |
dc.contributor.author | Abdel-Massih, Roula | en_US |
dc.contributor.author | Choudhary, Muhammad Iqbal | en_US |
dc.date.accessioned | 2020-12-23T09:09:19Z | - |
dc.date.available | 2020-12-23T09:09:19Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://scholarhub.balamand.edu.lb/handle/uob/2243 | - |
dc.description.abstract | Therapeutic potential of nandrolone and its derivatives against leishmaniasis has been studied. A number of derivatives of nandrolone (1) were synthesized through biotransformation. Microbial transformation of nandrolone (1) with Cunninghamella echinulata and Cunninghamella blakesleeana yielded three new metabolites, 10β,12β,17β-trihydroxy-19-nor-4-androsten-3-one (2), 10β,16α,17β-trihydroxy-19-nor-4-androsten-3-one (3), and 6β,10β,17β-trihydroxy-19-nor-4-androsten-3-one (4), along with four known metabolites, 10β,17β-dihydroxy-19-nor-4-androsten-3-one (5), 6β,17β-dihydroxy-19-nor-4-androsten-3-one (6) 10β-hydroxy-19-nor-4-androsten-3,17-dione (7) and 16β,17β-dihydroxy-19-nor-4-androsten-3-one (8). Compounds 1–8 were evaluated for their anti-leishmanial activity. Compounds 1 and 8 showed a significant activity in vitro against Leishmania major. The leishmanicidal potential of compounds 1–8 (IC50 = 32.0 ± 0.5, >100, 77.39 ± 5.52, 70.90 ± 1.16, 54.94 ± 1.01, 80.23 ± 3.39, 61.12 ± 1.39 and 29.55 ± 1.14 μM, respectively) can form the basis for the development of effective therapies against the protozoal tropical disease leishmaniasis. | en_US |
dc.format.extent | 5 p. | en_US |
dc.language.iso | eng | en_US |
dc.subject | Anabolic compound | en_US |
dc.subject | Cunninghamella echinulata | en_US |
dc.subject | Cunninghamella blakesleeana | en_US |
dc.subject | Leishmania major | en_US |
dc.subject | Leishmanicidal activity | en_US |
dc.subject.lcsh | Nandrolone | en_US |
dc.title | Microbial transformation of nandrolone with Cunninghamella echinulata and Cunninghamella blakesleeana and evaluation of leishmaniacidal activity of transformed products | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.1016/j.steroids.2014.06.020 | - |
dc.contributor.affiliation | Department of Biology | en_US |
dc.description.volume | 88 | en_US |
dc.description.startpage | 95 | en_US |
dc.description.endpage | 100 | en_US |
dc.date.catalogued | 2017-10-31 | - |
dc.description.status | Published | en_US |
dc.identifier.ezproxyURL | http://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1016/j.steroids.2014.06.020 | en_US |
dc.identifier.OlibID | 174624 | - |
dc.relation.ispartoftext | Steroids | en_US |
dc.provenance.recordsource | Olib | en_US |
Appears in Collections: | Department of Biology |
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