Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2195
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dc.contributor.authorHaber, Marc E.en_US
dc.contributor.authorDaher, Costantine F.en_US
dc.contributor.authorKaram, Marcen_US
dc.contributor.authorBaroody, Georgesen_US
dc.date.accessioned2020-12-23T09:08:16Z-
dc.date.available2020-12-23T09:08:16Z-
dc.date.issued2008-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2195-
dc.description.abstractInterleukin-13 (IL-13) is a powerful anti-inflammatory cytokine that was previously shown to be a susceptibility factor for Leishmania major (L. major) infection. In this study we report a different role for IL-13 in rats infected with L. major; rIL-13 stimulates expression of pro-inflammatory cytokines and IL-12 which is a key cytokine in protective immunity against Leishmania. Infected rats received daily injections of rIL-13 for eight consecutive days which resulted in increased pain perception for the first week post-infection assessed by thermal pain tests. This hyperalgesia was accompanied by a sustained early up-regulation of interleukin-1β followed by an up-regulation of IL-12p70. Real-time PCR showed no negative impact for rIL-13 upon the clearance of the parasites from the infection sites and blood.en_US
dc.format.extent5 p.en_US
dc.language.isoengen_US
dc.subjectLeishmania majoren_US
dc.subjectInterleukin-13en_US
dc.subjectPain testsen_US
dc.subjectImmunoassayen_US
dc.subject.lcshHyperalgesiaen_US
dc.titleLeishmania major : Interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1β and interleukin-12 in ratsen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.exppara.2008.11.004-
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.volume121en_US
dc.description.issue3en_US
dc.description.startpage224en_US
dc.description.endpage229en_US
dc.date.catalogued2019-05-07-
dc.description.statusPublisheden_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1016/j.exppara.2008.11.004en_US
dc.identifier.OlibID191657-
dc.relation.ispartoftextExperimental parasitology journalen_US
dc.provenance.recordsourceOliben_US
crisitem.author.parentorgFaculty of Arts and Sciences-
Appears in Collections:Department of Biology
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