Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/1905
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dc.contributor.authorHarakeh, Steveen_US
dc.contributor.authorAbdel-Massih, Roulaen_US
dc.contributor.authorGil, Pilar Riveraen_US
dc.contributor.authorSperling, Ralph A.en_US
dc.contributor.authorMeinhardt, Andreasen_US
dc.contributor.authorNeidwiecki, Aleksandraen_US
dc.date.accessioned2020-12-23T09:02:40Z-
dc.date.available2020-12-23T09:02:40Z-
dc.date.issued2010-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/1905-
dc.description.abstractThe role of PEG-coated gold nanoparticles (Au NPs) on the anti-proliferative effect of Specific Nutrient Synergy (SNS) on HTLV-1 infected (C91-PL and HuT-102) and non-infected (CEM and Jurkat) malignant T-lymphocytes cells, was investigated. When PEG-coated Au NPs (of different molecular weights) were added alone, there was no effect on either viability or proliferation of the leukemic cell lines studied. Treatment of cells with SNS and PEG (5 or 10 kDa) coated Au NP reduced significantly the proliferation in all cell lines tested; this reached more than 50% reduction as compared to the control for cells treated for 96 h. Data showed that the best anti-proliferative effect was obtained using SNS and Au NP coated with PEG of molecular weights of 5 and 10 kDa with almost no effect of PEG of lower molecular weights (0.75 and 2 kDa) or higher ones (20 kDa). This was true as well for HTLV-1 infected as for non-infected malignant T-lymphocytes. Electron microscopy results showed uptake of the gold particles to Jurkat cells. All described effects are specific to leukemia cell lines, and no effects were observed with freshly activated human mononuclear lymphocytes as control.en_US
dc.format.extent8 p.en_US
dc.language.isoengen_US
dc.subjectDrug deliveryen_US
dc.subjectNano-surfacesen_US
dc.subjectNanomedicineen_US
dc.subject.lcshNanoparticlesen_US
dc.subject.lcshNanoscienceen_US
dc.titleThe effect of PEG-coated gold nanoparticles on the anti-proliferative potential of Specific Nutrient Synergyen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3109/17435390903569621-
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.volume4en_US
dc.description.issue2en_US
dc.description.startpage177en_US
dc.description.endpage185en_US
dc.date.catalogued2017-10-31-
dc.description.statusPublisheden_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=http://dx.doi.org/10.3109/17435390903569621en_US
dc.identifier.OlibID174646-
dc.relation.ispartoftextNanotoxicologyen_US
dc.provenance.recordsourceOliben_US
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