Please use this identifier to cite or link to this item:
|Title:||Effect of age, gender and calciotropic hormones on the relationship between Vitamin D receptor gene polymorphisms and bone mineral density||Authors:||Arabi, Asma
Onsi, Lina El
Hajj Fuleihan , Ghada El
|Affiliations:||Faculty of Medicine||Issue Date:||2010||Part of:||European journal of clinical nutrition||Volume:||64||Start page:||383||End page:||391||Abstract:||
Background/Objectives: Hypovitaminosis D is a major public health problem worldwide and unexpectedly more so in sunny countries. Vitamin D receptor (VDR) gene is associated with inter-individual variance in bone mineral density (BMD). Studies assessing the effect of VDR gene polymorphisms on BMD yielded conflicting results. The aim of this study was to assess the relationship between VDR polymorphisms and BMD in the Lebanese, across age groups and genders and to assess the effect of PTH and lean mass and vitamin D levels on such relationship. Subjects/Methods: In total, 203 subjects aged 65–85 years and 336 children aged 10–17 years. Polymorphisms in the VDR gene were assessed with the restriction enzymes BsmI, TaqI and ApaI. Bone mineral content, BMD and lean mass were measured using Dual-Energy X-ray Absorptiometry (DXA). The dominant hand strength was measured in children. Results: Heterozygote genotype was the most frequent in both age groups. There was no difference in the frequency distribution of genotypes between the young and the elderly. No relationship between VDR genotypes and lean mass was found in either age group. Heterozygote boys had the lowest parathormone (PTH) and heterozygote elderly women had the highest BMD at the spine and forearm. Conclusions: In the Lebanese, the relationship between VDR polymorphisms and BMD differs by age. Survival does not seem to differ by VDR genotype. However, further studies are needed to assess the effect of VDR gene polymorphisms on mortality per se and time to mortality, not evaluated in this study.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/1882||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Faculty of Medicine|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.