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Title: The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species
Authors: Bilen, Melhem
Dufour, Jean-Charles
Cadoret, Frederic
Daoud, Ziad
Dubourg, Gregory
Raoult, Didier
Affiliations: Faculty of Medicine 
Issue Date: 2018
Part of: Journal of microbiome
Volume: 6
Issue: 1
Start page: 1
End page: 11
After a decade of research and metagenomic analyses, our knowledge of the human microbiota appears to have reached a plateau despite promising results. In many studies, culture has proven to be essential in describing new prokaryotic species and filling metagenomic gaps. In 2015, only 2172 different prokaryotic species were reported to have been isolated at least once from the human body as pathogens or commensals. In this review, we update the previous repertoire by reporting the different species isolated from the human body to date, increasing it by 28% to reach a total of 2776 species associated with human beings. They have been classified into 11 different phyla, mostly the Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria. Finally, culturomics contributed up to 66.2% towards updating this repertoire by reporting 400 species, of which 288 were novel. This demonstrates the need to continue the culturing work, which seems essential in order to decipher the hidden human microbial content.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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