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Title: Atropisomeric separation of a 2-aryl-imino-N-(2-aryl)-thiazoline compound by reversed phase HPLC using hydroxypropyl-g-cyclodextrin
Authors: Allouch, Ahmad
Hassan, Inas EL
Zeine, Abdel Razzak El
Bakkour, Youssef
Bouchkara, Mohammad
Nakat, Hanna El 
Omar, Fawaz El
Affiliations: Department of Chemistry 
Keywords: 2-aryl-imino-N-(2-aryl)-thiazoline
Atropisomeric separation
Issue Date: 2011
Part of: Asian journal of research in chemistry
Volume: 4
Issue: 11
Start page: 1800
End page: 1803
The fact that atropisomers of a biologically active compound exhibit different activities has attracted worldwide attention. The pharmacological activity of a chiral molecule can vary from one atropisomer to the other. Therefore, it is essential to separate the different atropisomers in order to be able to carry out the various biological tests; an inevitable step in the drug development process. In this study, the separation of racemic-N-[(2Z)-4-methyl-3-(2-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-N-(2-chlorophenyl)amine to collect its atropisomers has been achieved by HPLC using hydroxypropyl-?-cyclodextrin (HP???CD) (to obtain chiral molecules) and hexane-propane-2-ol as a mobile phase. The optimum conditions of resolution were established by systematically studying the effect of the mobile phase, the CD concentrations and the time of incubation of the CD-substrate.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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