Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7774
Title: Mesenchymal Stem Cell-Derived Secretome-Based Therapy for Neurological Disorders: A Scoping Review
Authors: Khalil, Charbel
Chebly, Alain
Harb, Frederic 
Abi Antoun, Fabienne
Akouche, Khalil
Khalil, Rita
Azar, Albert
Khalil, Maria
Chaar, Bahij
Abbas, Samar
Hanna, Colette
Ibrahim, Ahmad
Affiliations: Faculty of Medicine 
Keywords: Neurological disorders
Mesenchymal stem cells
Exosomes
Extracellular vesicles
Stem Cell Therapy
Issue Date: 2024-01-01
Publisher: Scientific Research
Part of: Stem Cell Discovery
Volume: 14
Issue: 1
Start page: 1
End page: 19
Abstract: 
Stem cells are the foundation of cellular therapy. They are multipotent cells capable of self-renewing and differentiating into several cell lineages. They are being investigated and used for the treatment of a wide range of diseases. There are various stem cell types and sources, with mesenchymal stem cells standing out as one noteworthy example. With neurological disorders being a major cause of deaths and disabilities worldwide, ongoing studies are investigating the therapeutic potential of mesenchymal stem cells for treating neuropathies. This review comprehensively outlines various neurological diseases and explores the therapeutic potential of mesenchymal stem cells in ischemic stroke, multiple sclerosis, ALS, Alzheimer’s, hypoxia, and glioblastoma. However, there are challenges and limitations in mesenchymal stem cell-based therapies, including concerns about immunocompatibility, maintenance of stemness and differentiation stability, and the potential risk of tumor formation.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7774
DOI: https://doi.org/10.4236/scd.2024.141001
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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