UOBScholar Hub
UOB Libraries created the UOBScholar Hub, an Institutional Repository (IR) for archiving and collecting all the research output of the UOB community. It aims to improve the visibility, usage and impact of research conducted at UOB. Materials included are: academic journal articles, conference papers and presentations, books and book chapters, ongoing research papers, reports and patents.
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https://scholarhub.balamand.edu.lb/handle/uob/7721| Title: | Insights into circulating CEACAM1 in insulin clearance and disease progression: Evidence from the Portuguese PREVADIAB2 study | Authors: | Patarrão, Rita S Meneses, Maria João Ghadieh, Hilda Herrera, Laura Duarte, Sérgio Ribeiro, Rogério T Raposo, João F Schmitt, Verena Singer, Bernhard B Gastaldelli, Amalia Penha-Gonçalves, Carlos Najjar, Sonia M Macedo, M Paula |
Affiliations: | Faculty of Medicine | Keywords: | CEACAM1 Diabetes Hepatic steatosis Hyperinsulinemia Insulin clearance Insulin resistance |
Issue Date: | 2024-12 | Publisher: | National Library of Medicine | Part of: | European Journal of Clinical Investigation | Volume: | 54 | Issue: | S2 | Abstract: | Type 2 diabetes (T2DM) and obesity are characterized by altered insulin metabolism and action. Reduced hepatic insulin clearance is increasingly recognized as a key contributor to hyperinsulinemia and insulin resistance. CEACAM1 promotes hepatic insulin clearance, and its loss in hepatocytes is associated with reduced insulin clearance in mice and men. This study examines whether CEACAM1 circulating levels reflect compromised insulin metabolism and resistance in the PREVADIAB2 cohort. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/7721 | ISSN: | 00142972 | DOI: | 10.1111/eci.14344 | Open URL: | Link to full text | Type: | Journal Article |
| Appears in Collections: | Faculty of Medicine |
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