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Title: Regulation of Insulin Clearance by Non-Esterified Fatty Acids
Authors: Najjar, Sonia M
Abdolahipour, Raziyeh
Ghadieh, Hilda 
Jahromi, Marziyeh Salehi
Najjar, John A
Abuamreh, Basil A M
Zaidi, Sobia
Kumarasamy, Sivarajan
Muturi, Harrison T
Affiliations: Faculty of Medicine 
Keywords: Hyperinsulinemia
Insulin clearance
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Non-esterified fatty acids
Issue Date: 2022-08-05
Publisher: National Library of Medicine
Part of: Biomedicines
Volume: 10
Issue: 8
Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance. This causes a reduction in insulin clearance as a compensatory mechanism to insulin resistance in obesity. On the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. Delineating the cause-effect relationship between reduced insulin clearance and insulin resistance has been complicated by the fact that insulin action and clearance are mechanistically linked to insulin binding to its receptors. This review discusses how NEFA mobilization contributes to the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and how this may be implicated in the pathogenesis of non-alcoholic fatty liver disease.
ISSN: 2227-9059
DOI: 10.3390/biomedicines10081899
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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