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Title: Determination of MIC, MPC, and MSW of Ilex paraguariensis against non-typhoidal Salmonella with identification of the mechanisms of resistance and pathogenicity factors
Authors: El Khatib, Khaled
Hadeer, Ribal Aby
Saad, Anis
Kalaydjian, Aline
Fayad, Elie
Mahfouz, Youssef
Dougnon, Victorien
Daoud, Ziad
Abdel-Massih, Roula M
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Keywords: Antibacterial activity
Antimicrobial resistance
Ilex paraguariensis
Virulence genes
Issue Date: 2023-01
Publisher: Elsevier
Part of: Microbial Pathogenesis
Volume: 174
This study investigated the antibacterial activity of the aqueous extract of Ilex paraguariensis against 32 different strains of nontyphoidal Salmonella (NTS) through the determination of the minimum inhibitory concentration (MIC), mutant prevention concentration (MPC), and mutant selection window (MSW) and the detection of virulence genes by multiplex PCR assays. The MIC values of Ilex paraguariensis against Salmonella spp. strains varied between 0.78 mg/ml and 6.25 mg/ml with a MIC90 of 3.12 mg/ml. The highest MPC in this study was 48 mg/ml yielding a mutant selection window of 41.75 mg/ml. The MSW values of the remaining strains varied between 1.56 and 8.87 mg/ml. Genes of pathogenicity detected in Salmonella spp. isolates were most commonly the stn, sdiA, invA, sopB, invH, and sopE genes. The antibacterial activity of yerba mate extract was not affected by the antimicrobial resistance patterns or pathogenicity genes expressed. More work is needed to identify the active antibacterial compound(s) responsible for the antibacterial activity.
ISSN: 08824010
DOI: 10.1016/j.micpath.2022.105905
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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