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Title: Contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of postthrombotic syndrome
Authors: Kreidy, Raghid
Affiliations: Faculty of Medicine 
Keywords: Deep vein thrombosis
Post-thrombotic syndrome
Issue Date: 2015
Publisher: National Library of Medicine
Part of: Clinical and Applied Thrombosis/Hemostasis
Volume: 21
Issue: 1
Start page: 87
End page: 90
Postthrombotic syndrome (PTS) is a common complication of deep vein thrombosis. This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.
ISSN: 10760296
DOI: 10.1177/1076029613497423
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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