Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/5881
DC Field | Value | Language |
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dc.contributor.author | Mossoro-Kpinde, Christian Diamant | en_US |
dc.contributor.author | Gody, Jean-Chrysostome | en_US |
dc.contributor.author | Mboumba Bouassa, Ralph-Sydney | en_US |
dc.contributor.author | Mbitikon, Olivia | en_US |
dc.contributor.author | Jenabian, Mohammad-Ali | en_US |
dc.contributor.author | Robin, Leman | en_US |
dc.contributor.author | Matta, Mathieu | en_US |
dc.contributor.author | Zeitouni, Kamal | en_US |
dc.contributor.author | Longo, Jean De Dieu | en_US |
dc.contributor.author | Costiniuk, Cecilia | en_US |
dc.contributor.author | Grésenguet, Gérard | en_US |
dc.contributor.author | Touré Kane, Ndèye Coumba | en_US |
dc.contributor.author | Bélec, Laurent | en_US |
dc.date.accessioned | 2022-07-19T08:48:19Z | - |
dc.date.available | 2022-07-19T08:48:19Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 00257974 | - |
dc.identifier.uri | https://scholarhub.balamand.edu.lb/handle/uob/5881 | - |
dc.description.abstract | A large cohort of 220 HIV-1-infected children (median [range] age: 12 [4-17] years) was cared and followed up in the Central African Republic, including 198 in 1st-line and 22 in 2nd-line antiretroviral regimens. Patients were monitored clinically and biologically for HIV-1 RNA load and drug resistance mutations (DRMs) genotyping. A total of 87 (40%) study children were virological responders and 133 (60%) nonresponders. In children with detectable viral load, the majority (129; 97%) represented a virological failure. In children receiving 1st-line regimens in virological failure for whom genotypic resistance test was available, 45% displayed viruses harboring at least 1 DRM to NNRTI or NRTI, and 26% showed at least 1 major DRM to NNRTI or NRTI; more than half of children in 1st-line regimens were resistant to 1st-generation NNRTI and 24% of the children in 1st-line regimens had a major DRMs to PI. Virological failure and selection of DRMs were both associated with poor adherence. These observations demonstrate high rate of virological failure after 3 to 5 years of 1st-line or 2nd-line antiretroviral treatment, which is generally associated with DRMs and therapeutic failure. Overall, more than half (55%) of children receiving 1st-line antiretroviral treatment for a median of 3.4 years showed virological failure and antiretroviral-resistance and thus eligible to 2nd-line treatment. Furthermore, two-third (64%) of children under 2nd-line therapy were eligible to 3rd-line regimen. Taken together, these observations point the necessity to monitor antiretroviral-treated children by plasma HIV-1 RNA load to diagnose as early as possible the therapeutic failure and operate switch to a new therapeutic line. | en_US |
dc.language.iso | eng | en_US |
dc.subject | Antiretroviral treatment | en_US |
dc.subject | Central Africa | en_US |
dc.subject | HIV-1 subtype | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Plasma HIV-1 RNA load | en_US |
dc.subject | Resistance mutations | en_US |
dc.subject | Virological failure | en_US |
dc.subject | Virological outcomes | en_US |
dc.title | High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.1097/MD.0000000000006282 | - |
dc.identifier.pmid | 28272247 | - |
dc.identifier.scopus | 2-s2.0-85015838029 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85015838029 | - |
dc.contributor.affiliation | Faculty of Medicine | en_US |
dc.description.volume | 96 | en_US |
dc.description.issue | 10 | en_US |
dc.date.catalogued | 2022-07-19 | - |
dc.description.status | Published | en_US |
dc.identifier.openURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348195/ | en_US |
dc.relation.ispartoftext | Medicine (United States) | en_US |
dc.description.campus | SGH campus | en_US |
Appears in Collections: | Faculty of Medicine |
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