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Title: Childhood adversities and post-traumatic stress disorder: evidence for stress sensitisation in the World Mental Health Surveys
Authors: McLaughlin, Katie A
Koenen, Karestan C
Bromet, Evelyn J
Karam, Elie G
Liu, Howard
Petukhova, Maria
Ruscio, Ayelet Meron
Sampson, Nancy A
Stein, Dan J
Aguilar-Gaxiola, Sergio
Alonso, Jordi
Borges, Guilherme
Demyttenaere, Koen
Dinolova, Rumyana V
Ferry, Finola
Florescu, Silvia
de Girolamo, Giovanni
Gureje, Oye
Kawakami, Norito
Lee, Sing
Navarro-Mateu, Fernando
Piazza, Marina
Pennell, Beth-Ellen
Posada-Villa, José
Ten Have, Margreet
Viana, Maria Carmen
Kessler, Ronald C
Affiliations: Faculty of Medicine 
Issue Date: 2017-11
Part of: British Journal of Psychiatry
Volume: 211
Issue: 5
Start page: 280
End page: 288
BackgroundAlthough childhood adversities are known to predict increased risk of post-traumatic stress disorder (PTSD) after traumatic experiences, it is unclear whether this association varies by childhood adversity or traumatic experience types or by age.AimsTo examine variation in associations of childhood adversities with PTSD according to childhood adversity types, traumatic experience types and life-course stage.MethodEpidemiological data were analysed from the World Mental Health Surveys (n = 27 017).ResultsFour childhood adversities (physical and sexual abuse, neglect, parent psychopathology) were associated with similarly increased odds of PTSD following traumatic experiences (odds ratio (OR) = 1.8), whereas the other eight childhood adversities assessed did not predict PTSD. Childhood adversity-PTSD associations did not vary across traumatic experience types, but were stronger in childhood-adolescence and early-middle adulthood than later adulthood.ConclusionsChildhood adversities are differentially associated with PTSD, with the strongest associations in childhood-adolescence and early-middle adulthood. Consistency of associations across traumatic experience types suggests that childhood adversities are associated with generalised vulnerability to PTSD following traumatic experiences.
ISSN: 00071250
DOI: 10.1192/bjp.bp.116.197640
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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