Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/5553
DC Field | Value | Language |
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dc.contributor.author | de Vries, Ymkje Anna | en_US |
dc.contributor.author | Al-Hamzawi, Ali | en_US |
dc.contributor.author | Alonso, Jordi | en_US |
dc.contributor.author | Andrade, Laura Helena | en_US |
dc.contributor.author | Benjet, Corina | en_US |
dc.contributor.author | Bruffaerts, Ronny | en_US |
dc.contributor.author | Bunting, Brendan | en_US |
dc.contributor.author | de Girolamo, Giovanni | en_US |
dc.contributor.author | Florescu, Silvia | en_US |
dc.contributor.author | Gureje, Oye | en_US |
dc.contributor.author | Haro, Josep Maria | en_US |
dc.contributor.author | Karam, Aimee | en_US |
dc.contributor.author | Kawakami, Norito | en_US |
dc.contributor.author | Kovess-Masfety, Viviane | en_US |
dc.contributor.author | Lee, Sing | en_US |
dc.contributor.author | Mneimneh, Zeina | en_US |
dc.contributor.author | Navarro-Mateu, Fernando | en_US |
dc.contributor.author | Ojagbemi, Akin | en_US |
dc.contributor.author | Posada-Villa, José | en_US |
dc.contributor.author | Scott, Kate | en_US |
dc.contributor.author | Stagnaro, Juan Carlos | en_US |
dc.contributor.author | Torres, Yolanda | en_US |
dc.contributor.author | Xavier, Miguel | en_US |
dc.contributor.author | Zarkov, Zahari N | en_US |
dc.contributor.author | Kessler, Ronald C | en_US |
dc.contributor.author | de Jonge, Peter | en_US |
dc.contributor.author | Karam, Elie | en_US |
dc.date.accessioned | 2022-05-10T07:35:00Z | - |
dc.date.available | 2022-05-10T07:35:00Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 00332917 | - |
dc.identifier.uri | https://scholarhub.balamand.edu.lb/handle/uob/5553 | - |
dc.description.abstract | Background Depressive and anxiety disorders are highly comorbid, which has been theorized to be due to an underlying internalizing vulnerability. We aimed to identify groups of participants with differing vulnerabilities by examining the course of internalizing psychopathology up to age 45. Methods We used data from 24158 participants (aged 45+) in 23 population-based cross-sectional World Mental Health Surveys. Internalizing disorders were assessed with the Composite International Diagnostic Interview (CIDI). We applied latent class growth analysis (LCGA) and investigated the characteristics of identified classes using logistic or linear regression. Results The best-fitting LCGA solution identified eight classes: a healthy class (81.9%), three childhood-onset classes with mild (3.7%), moderate (2.0%), or severe (1.1%) internalizing comorbidity, two puberty-onset classes with mild (4.0%) or moderate (1.4%) comorbidity, and two adult-onset classes with mild comorbidity (2.7% and 3.2%). The childhood-onset severe class had particularly unfavorable sociodemographic outcomes compared to the healthy class, with increased risks of being never or previously married (OR = 2.2 and 2.0, p < 0.001), not being employed (OR = 3.5, p < 0.001), and having a low/low-average income (OR = 2.2, p < 0.001). Moderate or severe (v. mild) comorbidity was associated with 12-month internalizing disorders (OR = 1.9 and 4.8, p < 0.001), disability (B = 1.1–2.3, p < 0.001), and suicidal ideation (OR = 4.2, p < 0.001 for severe comorbidity only). Adult (v. childhood) onset was associated with lower rates of 12-month internalizing disorders (OR = 0.2, p < 0.001). Conclusions We identified eight transdiagnostic trajectories of internalizing psychopathology. Unfavorable outcomes were concentrated in the 1% of participants with childhood onset and severe comorbidity. Early identification of this group may offer opportunities for preventive interventions. | en_US |
dc.language.iso | eng | en_US |
dc.subject | Anxiety disorders | en_US |
dc.subject | Depression | en_US |
dc.subject | Internalizing disorders | en_US |
dc.subject | Latent class growth analysis | en_US |
dc.title | Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.1017/S0033291720004031 | - |
dc.identifier.pmid | 33168122 | - |
dc.identifier.scopus | 2-s2.0-85095992614 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85095992614 | - |
dc.contributor.affiliation | Faculty of Medicine | en_US |
dc.description.volume | 52 | en_US |
dc.description.issue | 11 | en_US |
dc.description.startpage | 2134 | en_US |
dc.description.endpage | 2143 | en_US |
dc.date.catalogued | 2022-05-10 | - |
dc.description.status | Published | en_US |
dc.identifier.ezproxyURL | http://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1017/S0033291720004031 | en_US |
dc.relation.ispartoftext | Psychological Medicine | en_US |
dc.description.campus | SGH campus | en_US |
Appears in Collections: | Faculty of Medicine |
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