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dc.contributor.authorde Vries, Ymkje Annaen_US
dc.contributor.authorAl-Hamzawi, Alien_US
dc.contributor.authorAlonso, Jordien_US
dc.contributor.authorAndrade, Laura Helenaen_US
dc.contributor.authorBenjet, Corinaen_US
dc.contributor.authorBruffaerts, Ronnyen_US
dc.contributor.authorBunting, Brendanen_US
dc.contributor.authorde Girolamo, Giovannien_US
dc.contributor.authorFlorescu, Silviaen_US
dc.contributor.authorGureje, Oyeen_US
dc.contributor.authorHaro, Josep Mariaen_US
dc.contributor.authorKaram, Aimeeen_US
dc.contributor.authorKawakami, Noritoen_US
dc.contributor.authorKovess-Masfety, Vivianeen_US
dc.contributor.authorLee, Singen_US
dc.contributor.authorMneimneh, Zeinaen_US
dc.contributor.authorNavarro-Mateu, Fernandoen_US
dc.contributor.authorOjagbemi, Akinen_US
dc.contributor.authorPosada-Villa, Joséen_US
dc.contributor.authorScott, Kateen_US
dc.contributor.authorStagnaro, Juan Carlosen_US
dc.contributor.authorTorres, Yolandaen_US
dc.contributor.authorXavier, Miguelen_US
dc.contributor.authorZarkov, Zahari Nen_US
dc.contributor.authorKessler, Ronald Cen_US
dc.contributor.authorde Jonge, Peteren_US
dc.contributor.authorKaram, Elieen_US
dc.description.abstractBackground Depressive and anxiety disorders are highly comorbid, which has been theorized to be due to an underlying internalizing vulnerability. We aimed to identify groups of participants with differing vulnerabilities by examining the course of internalizing psychopathology up to age 45. Methods We used data from 24158 participants (aged 45+) in 23 population-based cross-sectional World Mental Health Surveys. Internalizing disorders were assessed with the Composite International Diagnostic Interview (CIDI). We applied latent class growth analysis (LCGA) and investigated the characteristics of identified classes using logistic or linear regression. Results The best-fitting LCGA solution identified eight classes: a healthy class (81.9%), three childhood-onset classes with mild (3.7%), moderate (2.0%), or severe (1.1%) internalizing comorbidity, two puberty-onset classes with mild (4.0%) or moderate (1.4%) comorbidity, and two adult-onset classes with mild comorbidity (2.7% and 3.2%). The childhood-onset severe class had particularly unfavorable sociodemographic outcomes compared to the healthy class, with increased risks of being never or previously married (OR = 2.2 and 2.0, p < 0.001), not being employed (OR = 3.5, p < 0.001), and having a low/low-average income (OR = 2.2, p < 0.001). Moderate or severe (v. mild) comorbidity was associated with 12-month internalizing disorders (OR = 1.9 and 4.8, p < 0.001), disability (B = 1.1–2.3, p < 0.001), and suicidal ideation (OR = 4.2, p < 0.001 for severe comorbidity only). Adult (v. childhood) onset was associated with lower rates of 12-month internalizing disorders (OR = 0.2, p < 0.001). Conclusions We identified eight transdiagnostic trajectories of internalizing psychopathology. Unfavorable outcomes were concentrated in the 1% of participants with childhood onset and severe comorbidity. Early identification of this group may offer opportunities for preventive interventions.en_US
dc.subjectAnxiety disordersen_US
dc.subjectInternalizing disordersen_US
dc.subjectLatent class growth analysisen_US
dc.titleTransdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys reporten_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.relation.ispartoftextPsychological Medicineen_US
dc.description.campusSGH campusen_US
Appears in Collections:Faculty of Medicine
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