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dc.contributor.authorMaalouly, Josephen_US
dc.contributor.authorEl Assaad, Donnaen_US
dc.contributor.authorAyoubi, Ramien_US
dc.contributor.authorTawk, Antoniosen_US
dc.contributor.authorDarwish, Mohammaden_US
dc.contributor.authorAouad, Danyen_US
dc.contributor.authorLati, Georgioen_US
dc.contributor.authorDarwish, Mohammaden_US
dc.contributor.authorEl Rassi, Georgeen_US
dc.description.abstractIntroduction Total knee arthroplasty (TKA) are associated with significant postoperative blood loss. Tranexamic acid (TXA) is a potent agent with antifibrinolytic activity, that can be administered via the intravenous (IV) and/or topical (intra-articular, IA) route, which can possibly interrupt the cascade of events due to hemostatic irregularities close to the source of bleeding. However, the literature contains scarce scientific evidence related to IV only TXA usage in TKA. The current study aims to compare the outcome between patients who were administered IV TXA and a control group in terms of blood loss, transfusion rate, and incidence of deep vein thrombosis (DVT) and thromboembolism (TE). Methods 110 patients, who underwent TKA were placed into two groups: 1) 34 patients who received IV TXA; and 2) 76 patients in the control group. In the TXA group, patients received an IV TXA dose of 1 g, 30 min before incision. Two drains were placed. Results Usage of IV TXA showed better results when compared to the control group in terms of mean blood transfusion (0.5 less transfusion during hospital stay), hemoglobin drop (10%). No cases of DVT or TE were noted among the two study groups. Conclusion Use of IV TXA provided significantly better results compared to no TXA use with respect to all variables related to postoperative blood loss in TKA. Moreover, TXA use is safe in terms of incidence of symptomatic DVT and TE.en_US
dc.publisherNational Library of Medicineen_US
dc.subjectAllogeneic blood transfusionen_US
dc.subjectBlood lossen_US
dc.subjectTotal knee arthroplastyen_US
dc.titleEfficacy and safety of systemic tranexamic acid administration in total knee arthroplasty: A case seriesen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.relation.ispartoftextInternational Journal of Surgery Case Reportsen_US
dc.description.campusSGH campusen_US
Appears in Collections:Faculty of Medicine
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