Please use this identifier to cite or link to this item:
DC FieldValueLanguage
dc.contributor.advisorChakass, Dania Nadim.en_US
dc.contributor.authorHwalla, Samihen_US
dc.descriptionIncludes bibliographical references (p.72-78).en_US
dc.descriptionSupervised by Dr. Dania Awad.en_US
dc.description.abstractThe aim of this research work is to study the effect of colitis or colonic inflammation induced by IA (iodoacetamide), TNBS (trinitrobenzene sulfonic acid) and DSS (dextransulfate sodium), on the absorptive capacity of the small intestine for glucose and water in adult Sprague-Dawley rats. The rate of glucose absorption was examined by the in vivo single pass perfusion technique in the jejunum and ileum and the mRNA level of expression of glucose transporters and aquaporins was determined in the small intestine in experimental colitis. The results have shown a significant decrease in the absorptive capacity for glucose in the jejunum, but not in the ileum. In addition, a significant decrease in the level of mRNA expression of SGLT1, GLUT2, GLUT5, AQP1, AQP7, AQP8 and Na+ -K+ -ATPase in the small intestine in all experimental colitis models. Moreover, a significant decrease of AQP1, AQP8 and Na+ -K+ -ATPase mRNA expression was detected in the colon. The present research indicated that a cross-talk exist between the inflamed colon and the small intestine. We suggest that this cross-talk may be controlled by a neural and/or an immunological mechanism.en_US
dc.description.statementofresponsibilityBy Samih Hwallaen_US
dc.format.extentxii, 78 p. :ill., tables ;30 cmen_US
dc.rightsThis object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holderen_US
dc.subject.lcshIntestinal absorptionen_US
dc.subject.lcshGastrointestinal systemen_US
dc.titleThe effect of experimental colitis on glucose absorption and aquaporin expression in the small intestine in adult ratsen_US
dc.title.alternativeThe effect of experimental colitis on glucose absorption & aquaporin expression in the small intestine in adult ratsen_US
dc.contributor.facultyFaculty of Medicine and Medical Sciencesen_US
dc.contributor.institutionUniversity of Balamanden_US
dc.description.degreeMS in Biomedical Sciencesen_US
Appears in Collections:UOB Theses and Projects
Show simple item record

Record view(s)

checked on Dec 4, 2021

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.