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dc.contributor.advisorKaram, Marcen_US
dc.contributor.authorGhadieh, Hildaen_US
dc.descriptionIncludes bibliographical references (p.59-78).en_US
dc.descriptionSupervised by Dr. Marc Karam.en_US
dc.description.abstractBackground: Atherosclerosis is a progressive inflammatory disease marked by the development of a plaque within the injured arterial wall in response to various harmful insults. Although regulatory T cells (Tregs) and Th-17 cells might be implicated in antagonistic functions, transforming growth factor β (TGF-β) could be required for the differentiation of these two T-cell subsets. Objective: The aim of our study was to investigate the immunomodulatory effect of ox-LDL and/or TGF-β in patients with stable angina and normal subjects. Methods: Peripheral blood mononuclear cells (PBMCs) from stable angina (SA) and normal coronary arteries (NCA) subjects were treated in vitro with ox-LDL, TGF-β alone or in combination. Under these conditions, the frequency of Treg cells was assessed after four days of incubation. Moreover; the release of the signature Treg cytokine, IL-10, as well as the Th17 related cytokines IL-17 were quantified in the supernatant of PBMC cultures from patients and controls. Results: Our results showed that only patients were vulnerable to an increase in IL17 levels after treatment with ox-LDL and TGF-β. However, there was no significant difference in the percentages of Treg cells and IL-10 secretion levels between NCA and SA groups. Conclusions: We suggest that the maintained peripheral cellular tolerance in patients suffering from a stable angina pectoris might be altered under the effect of specific cytokines and lipoproteins concentration that can exist in the cell culture media. This microenvironment is able to modulate the inflammatory or anti-inflammatory responses of the immune system.en_US
dc.description.statementofresponsibilityBy Hilda Ghadiehen_US
dc.format.extentxi, 82 p. :ill., tables ;30 cmen_US
dc.rightsThis object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holderen_US
dc.titleThe immunomodulatory effect of Oxidized-LDL and/or transforming growth factor-β on peripheral T cell-mediated immune responses in patients with stable anginaen_US
dc.title.alternativeThe immunomodulatory effect of Oxidized-LDL &/or transforming growth factor-β on peripheral T cell-mediated immune responses in patients with stable anginaen_US
dc.contributor.departmentDepartment of Biologyen_US
dc.contributor.facultyFaculty of Arts and Sciencesen_US
dc.contributor.institutionUniversity of Balamanden_US
dc.description.degreeMSc in Biologyen_US
Appears in Collections:UOB Theses and Projects
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