Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2683
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dc.contributor.authorEchtay, Karimen_US
dc.contributor.authorBienengraeber, Martinen_US
dc.contributor.authorMayinger, Peteren_US
dc.contributor.authorHeimpel, Simoneen_US
dc.contributor.authorWinkler, Edithen_US
dc.contributor.authorDruhmann, Doertheen_US
dc.contributor.authorFrischmuth, Karinaen_US
dc.contributor.authorKamp, Fritsen_US
dc.contributor.authorHuang, Shu-Guien_US
dc.date.accessioned2020-12-23T09:18:15Z-
dc.date.available2020-12-23T09:18:15Z-
dc.date.issued2018-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2683-
dc.description.abstractThe uncoupling protein (UCP1) is a proton (H+) transporter in the mitochondrial inner membrane. By dissipating the electrochemical H+ gradient, UCP1 uncouples respiration from ATP synthesis, which drives an increase in substrate oxidation via the TCA cycle flux that generates more heat. The mitochondrial uncoupling-mediated non-shivering thermogenesis in brown adipose tissue is vital primarily to mammals, such as rodents and new-born humans, but more recently additional functions in adult humans have been described. UCP1 is regulated by β-adrenergic receptors through the sympathetic nervous system and at the molecular activity level by nucleotides and fatty acid to meet thermogenesis needs. The discovery of novel UCP homologs has greatly contributed to the understanding of human diseases, such as obesity and diabetes. In this article, we review the progress made towards the molecular mechanism and function of the UCPs, in particular focusing on the influential contributions from Martin Klingenberg's laboratory. Because all members of the UCP family are potentially promising drug targets, we also present and discuss possible approaches and methods for UCP-related drug discovery.en_US
dc.format.extent15 p.en_US
dc.language.isoengen_US
dc.subjectUncoupling proteinen_US
dc.subjectNon-shivering thermogenesisen_US
dc.subjectBrown adipose tissueen_US
dc.subjectSolute transporten_US
dc.subjectDrug discoveryen_US
dc.subject.lcshMitochondriaen_US
dc.subject.lcshObesityen_US
dc.titleUncoupling proteins : Martin Klingenberg's contributions for 40 yearsen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.abb.2018.09.006-
dc.contributor.affiliationFaculty of Medicineen_US
dc.description.volume657en_US
dc.description.startpage41en_US
dc.description.endpage55en_US
dc.date.catalogued2018-11-12-
dc.description.statusPublisheden_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=https://doi.org/10.1016/j.abb.2018.09.006en_US
dc.identifier.OlibID187110-
dc.relation.ispartoftextJournal of archives of biochemistry and biophysicsen_US
dc.provenance.recordsourceOliben_US
Appears in Collections:Faculty of Medicine
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