Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2540
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dc.contributor.authorEchtay, Karimen_US
dc.contributor.authorEsteves, Telma C.en_US
dc.contributor.authorPakay, Julian L.en_US
dc.contributor.authorJekabsons, Mika B.en_US
dc.contributor.authorLambert, Adrian J.en_US
dc.contributor.authorPortero‐Otín, Manuelen_US
dc.contributor.authorPamplona, Reinalden_US
dc.contributor.authorVidal‐Puig, Antonio J.en_US
dc.contributor.authorWang, Stevenen_US
dc.contributor.authorRoebuck, Stephen J.en_US
dc.contributor.authorBrand, Martin Den_US
dc.date.accessioned2020-12-23T09:15:19Z-
dc.date.available2020-12-23T09:15:19Z-
dc.date.issued2003-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2540-
dc.description.abstractOxidative stress and mitochondrial dysfunction are associated with disease and aging. Oxidative stress results from overproduction of reactive oxygen species (ROS), often leading to peroxidation of membrane phospholipids and production of reactive aldehydes, particularly 4‐hydroxy‐2‐nonenal. Mild uncoupling of oxidative phosphorylation protects by decreasing mitochondrial ROS production. We find that hydroxynonenal and structurally related compounds (such as trans‐retinoic acid, trans‐retinal and other 2‐alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT). Hydroxynonenal‐induced uncoupling was inhibited by potent inhibitors of ANT (carboxyatractylate and bongkrekate) and UCP (GDP). The GDP‐sensitive proton conductance induced by hydroxynonenal correlated with tissue expression of UCPs, appeared in yeast mitochondria expressing UCP1 and was absent in skeletal muscle mitochondria from UCP3 knockout mice. The carboxyatractylate‐sensitive hydroxynonenal stimulation correlated with ANT content in mitochondria from Drosophila melanogaster expressing different amounts of ANT. Our findings indicate that hydroxynonenal is not merely toxic, but may be a biological signal to induce uncoupling through UCPs and ANT and thus decrease mitochondrial ROS production.en_US
dc.format.extent8 p.en_US
dc.language.isoengen_US
dc.subjectANTen_US
dc.subjectHydroxynonenalen_US
dc.subjectOxidative stressen_US
dc.subjectUCPen_US
dc.subject.lcshObesityen_US
dc.titleA signalling role for 4 - hydroxy - 2 - nonenal in regulation of mitochondrial uncouplingen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.description.volume22en_US
dc.description.startpage4103en_US
dc.description.endpage4110en_US
dc.date.catalogued2017-12-14-
dc.description.statusPublisheden_US
dc.identifier.OlibID175613-
dc.identifier.openURLhttp://emboj.embopress.org/content/22/16/4103en_US
dc.relation.ispartoftextEMBO journalen_US
dc.provenance.recordsourceOliben_US
Appears in Collections:Faculty of Medicine
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