Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2405
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dc.contributor.authorBassil, Naji Miladen_US
dc.contributor.authorAbdel-Massih, Roulaen_US
dc.contributor.authorEl-Chami, Nisrineen_US
dc.contributor.authorSmith, Colinen_US
dc.contributor.authorBaydoun, Elias A-H.en_US
dc.date.accessioned2020-12-23T09:12:35Z-
dc.date.available2020-12-23T09:12:35Z-
dc.date.issued2012-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2405-
dc.description.abstractWe tested the effect of ethanol extracts from Ruscus aculeatus (Asparagaceae) and Pleurotus ostreatus (Agaricales) on the survival and proliferation of the Jurkat cell line, a model of human acute T-cell lymphocytic leukemia. R. aculeatus extracts were toxic to both Jurkat cells and human primary lymphocytes. P. ostreatus extracts were significantly more toxic to Jurkat cells than primary lymphocytes, as seen by LDH release and MTT assays. Annexin-V detection as well as Bax, Bcl-2, Smac/Diablo, and Caspase-8 expression were largely unchanged by P. ostreatus extracts. Cell cycle analysis and CDK-4 expression revealed stop of Jurkat cell proliferation. Interestingly, both extracts cause a strong, dose-dependent decrease in p53 levels in Jurkat cells, consistent with toxicity and cell death occurring via an unknown, non-apoptotic mechanism.en_US
dc.format.extent10 p.en_US
dc.language.isoengen_US
dc.subjectAcute lymphocytic leukemiaen_US
dc.subjectJurkaten_US
dc.subjectPleurotus ostreatusen_US
dc.subjectRuscus aculeatusen_US
dc.titlePleurotus ostreatus and ruscus aculeatus extracts cause non-apoptotic jurkat cell deathen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.volume1en_US
dc.description.issue1en_US
dc.description.startpage14en_US
dc.description.endpage24en_US
dc.date.catalogued2017-10-31-
dc.description.statusPublisheden_US
dc.identifier.OlibID174634-
dc.identifier.openURLhttp://www.ccsenet.org/journal/index.php/jps/article/view/12346en_US
dc.relation.ispartoftextJournal of plant studiesen_US
dc.provenance.recordsourceOliben_US
Appears in Collections:Department of Biology
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