Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2264
Title: Molecular recognition by Kluyveromyces of amphotericin B-loaded, galactose-tagged, poly (lactic acid) microspheres
Authors: Kassab, Rima 
Parrot-Loppez, Hélen
Fessi, Hatem
Menaucourt, Jean
Bonaly, Roger
Coulon, Joël
Affiliations: Department of Chemistry 
Issue Date: 2002
Part of: Bioorganic and medicinal chemistry
Volume: 10
Issue: 6
Start page: 1767
End page: 1775
Abstract: 
In an effort to develop a new way of drug delivery, especially for polyenic antifungal molecules, we have incorporated amphotericin B (AmB) into biodegradable galactosylated poly (l-lactic acid) (l-PLA) and poly (l-lactic-co-glycolic acid) (PLGA) microspheres. These drug carriers were prepared by solvent evaporation using an oil/water (o/w) emulsion. The ratio of galactosyl spacers with different chain lengths was 1.74–2.78%. The maximal quantity of AmB encapsulated reported to 100 mg of the galactosylated microspheres was 7.14 mg for l-PLA (encapsulation rate 45% of mole) and 6.42 mg for PLGA derivatives (encapsulation rate 81% of mole). In our yeast model, drug release depended on three factors: (i) presence of galactosylated antennae, (ii) length of galactosyl antenna and (iii) nature of the polymer. More of the AmB trapped in PLGA microspheres was released than from PLA microspheres. These novel functionalised microspheres could be required for the delivering of therapeutic agents according to their recognition to specific cells. We have incorporated amphotericin B (AmB) into biodegradable galactosylated poly (l-lactic acid) (l-PLA) and poly (l-lactic-co-glycolic acid) (PLGA) microspheres. These novel functionalised microspheres could be required for the delivering of bioactive molecules according to their recognition to specific cells.
URI: https://scholarhub.balamand.edu.lb/handle/uob/2264
DOI: 10.1016/S0968-0896(02)00028-7
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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