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Title: Microspheres containing doxycycline: properties and vitro study
Authors: Kassab, Rima 
Yammine, Paolo 
Moussa, Dima
Safi, Nahed
Affiliations: Department of Chemistry 
Department of Chemistry 
Keywords: Poly(DL-lactide)
Solvent evaporation technique
Drug release
Drug delivery
Issue Date: 2013
Part of: International journal of drug delivery
Volume: 5
Issue: 3
Start page: 264
End page: 269
PLA microspheres loaded with the antibiotic Doxycycline are prepared using solvent evaporation technique (o/w) by varying the drug masses. They are evaluated for drug encapsulation, drug loading, particle size, morphology, FT-IR, stability and in vitro release. Microspheres loaded with Doxycycline show a maximum drug encapsulation of 38%. They exhibit homogeneous size distribution varying between 80 and 110 µm, with a spherical profile and porous surface. FT-IR study hasnt revealed any drug-polymer interaction. After 6 months of storage at different conditions, no appreciable difference is observed concerning the degradation of microspheres. In vitro release study of PLA microspheres loaded with Doxycycline reveals a rather fast release which requires only few hours to go to completion.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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