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|Title:||Microspheres containing doxycycline : Properties and vitro study||Authors:||Kassab, Rima
|Affiliations:||Department of Chemistry
Department of Chemistry
Solvent evaporation technique
|Issue Date:||2013||Part of:||International journal of drug delivery||Volume:||5||Issue:||3||Start page:||264||End page:||269||Abstract:||
PLA microspheres loaded with the antibiotic Doxycycline are prepared using solvent evaporation technique (o/w) by varying the drug masses. They are evaluated for drug encapsulation, drug loading, particle size, morphology, FT-IR, stability and in vitro release. Microspheres loaded with Doxycycline show a maximum drug encapsulation of 38%. They exhibit homogeneous size distribution varying between 80 and 110 µm, with a spherical profile and porous surface. FT-IR study hasnt revealed any drug-polymer interaction. After 6 months of storage at different conditions, no appreciable difference is observed concerning the degradation of microspheres. In vitro release study of PLA microspheres loaded with Doxycycline reveals a rather fast release which requires only few hours to go to completion.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/2244||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Chemistry|
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