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Title: Interleukin-13 reduces hyperalgesia and the level of interleukin-1β in BALB/c mice infected with Leishmania major with an up-regulation of interleukin-6
Authors: Karam, Marc 
Kouba, Jane Al
Bazzi, Samer 
Bodman-Smith, Kikki
Leung, Lawrence
Affiliations: Department of Biology 
Department of Biology 
Keywords: Leishmania major
Sympathetic amines
Peripheral sensitization
Central sensitization
Subjects: Hyperalgesia
Issue Date: 2011
Part of: Journal of neuroimmunology
Volume: 234
Issue: 1-2
Start page: 49
End page: 54
The anti-inflammatory cytokines interleukin-10 (IL-10) and interleukin-13 (IL-13) were shown to reduce hyperalgesia in some models such as rats exposed to UV rays. In addition, IL-10 was also shown to reduce hyperalgesia in high dose of Leishmania major-induced inflammation in BALB/c mice accompanied by a significant decrease in the levels of interleukin-1β (IL-1β) in the paws of infected mice, while no effect on the levels of IL-6 was observed. In this study, we injected BALB/c mice with a high dose of L. major and treated them with IL-13 (15 ng/animal) for twelve days (excluding the weekends) and hyperalgesia was assessed using thermal pain tests. Furthermore, the levels of IL-1β and IL-6 were also assessed at different post-infection days. Our results show that IL-6 and more importantly IL-1β don't play a direct role in the L. major-induced hyperalgesia and that IL-13 induces this hyperalgesia through the down-regulation of IL-1β and another proinflammatory cytokine (most probably TNF-α). Furthermore, our data show that IL-13 leads to the upregulation of the level IL-6 which initially seems to have no direct role in the induced hyperalgesia. Therefore, we suggest that the L. major-induced hyperalgesia is mainly mediated by the cytokine cascade leading to the production of sympathetic amines.
DOI: 10.1016/j.jneuroim.2011.02.003
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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