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dc.contributor.authorChallita, Carenen_US
dc.contributor.authorDahdouh, Eliasen_US
dc.contributor.authorAttieh, Michelen_US
dc.contributor.authorDandachi, Imanen_US
dc.contributor.authorRagheb, Elioen_US
dc.contributor.authorTaoutel, Royen_US
dc.contributor.authorTanba, Carlen_US
dc.contributor.authorDaoud, Ziaden_US
dc.description.abstractMuti-Drug Resistant Organisms (MDROs) are problematic all over the world, especially in Lebanon. High fecal carriage rates of MDR Enterobacteriaceae were reported from Lebanese nursing homes. Some studies show that MDROs have a fitness cost as compared to sensitive isolates. In this study, the competitive growth of MDR Escherichia coli obtained from fecal samples from elderly is assessed. Fecal swabs from ten elderly patients from a Lebanese nursing home were obtained between June and December, 2015. Isolates were identified by API 20E and antimicrobial susceptibilities were determined. Production of ESBL (extended spectrum β lactamase), MBL (metallo β lactamse), AmpC and KPC (Klebsiella pneumonia carbapenemase) was detected phenotypically by the use of EDTA, PBA, cloxacillin, and DDSTs. In-vitro competition assays were performed using E. coli isolates with different combinations of bacterial resistance. A total of 117 isolates was obtained with 71.8% E. coli, 7.7% of which were ESBL and 5.1% AmpC producers. Sensitive E. coli isolates out-competed all other isolates when in competition, followed sequentially by ESBL, AmpC, and OXA-48 (oxacillin) producers. This study shows an advantage of sensitive E. coli strains obtained from fecal samples to out-compete resistant strains in specific in-vitro conditions. This ability could be exploited in the elimination of MDR organisms from the gut flora, after further investigation.en_US
dc.subjectMulti-Drug Resistant Organismsen_US
dc.subjectFecal carriageen_US
dc.subjectFitness costen_US
dc.subjectNursing homesen_US
dc.titleFecal carriage of MDROs in a population of Lebanese elderly: dynamics and impact on bacterial fitnessen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.relation.ispartoftextJournal of infection and public healthen_US
Appears in Collections:Faculty of Medicine
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